| Gene Symbol | CHST2 |
|---|---|
| Entrez Gene | 9435 |
| Alt Symbol | C6ST, GST-2, GST2, Gn6ST-1, HEL-S-75, glcNAc6ST-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 |
| Other Description | N-acetylglucosamine 6-O-sulfotransferase 1|carbohydrate (chondroitin 6/keratan) sulfotransferase 2|carbohydrate sulfotransferase 2|epididymis secretory protein Li 75|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2 |
| Swissprots | Q9UED5 Q2M370 Q9Y4C5 D3DNG5 Q9Y6F2 Q9GZN5 |
| Accessions | BAB16887 EAW78952 EAW78953 Q9Y4C5 AB014679 BAA34265 AB014680 BAA34266 AB021124 BAB16886 AF083066 AAD20981 AK023268 BAG51179 BC017499 BC036930 BC042160 BC068604 BC105010 AAI05011 BC105012 AAI05013 BX387933 CA431595 EU668328 ACF94481 EU832159 ACE87509 EU832253 ACE86823 NM_004267 NP_004258 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. {ECO:0000269|PubMed:11042394}. |
| Subcellular Location | Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:22260995}; Single-pass type II membrane protein {ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:22260995}. |
| Tissue Specificity | Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes. {ECO:0000269|PubMed:10049591, ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:9722682}. |
| Top Pathways | Glycosaminoglycan biosynthesis - keratan sulfate |