| Gene Symbol | drk |
|---|---|
| Entrez Gene | 36497 |
| Alt Symbol | 24/1, CG6033, DRK, Dmel\CG6033, Drk, Drk/Grb2, E(sev)2B, GRB2, Grb-2, Grb/drk, Grb2, Grb2/drk, P1112, Su(sev)R1, crkl, l(2)10626, l(2)k13809 |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | downstream of receptor kinase |
| Other Description | CG6033-PA|CG6033-PB|CG6033-PC|CG6033-PD|CG6033-PF|downstream of receptor kinases|downstream receptor kinase|drk-PA|drk-PB|drk-PC|drk-PD|drk-PF|enhancer of sevenless-2B |
| Swissprots | A4UZF9 Q0E989 Q9V6Q5 Q08012 |
| Accessions | AAF58368 AAM68581 AAM68582 AAM68583 AAM68585 AAN17564 AAN17565 AAN17566 AAN17567 AAN17568 AAN17569 AAN17570 AAN17571 AAN17572 AAN17573 AAN17574 AAN17575 AAN17576 AAN17577 AAN17578 AAN17579 AAN17580 AAN17581 AAN17582 AAN17583 AAN17584 AAN17585 Q08012 AY061142 AAL28690 L12446 AAA28898 NM_057510 NP_476858 NM_165994 NP_725302 NM_165995 NP_725303 NM_165996 NP_725304 NM_165998 NP_725306 |
| Function | Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex. {ECO:0000269|PubMed:8462097, ECO:0000269|PubMed:8462098}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:8462098}; Peripheral membrane protein {ECO:0000269|PubMed:8462098}. |
| Tissue Specificity | Found mainly in the developing eye and in the antennal disk. Also observed in other imaginal disks tested and in the embryo. |
| Top Pathways | Jak-STAT signaling pathway, Dorso-ventral axis formation, MAPK signaling pathway - fly |