E2F2

Gene Symbol E2F2
Entrez Gene 1870
Alt Symbol E2F-2
Species Human
Gene Type protein-coding
Description E2F transcription factor 2
Other Description transcription factor E2F2
Swissprots Q14209 B2R9W1 Q7Z6H1
Accessions AAM54044 EAW95055 EAW95056 EAW95057 EAW95058 Q14209 AF086395 AK092799 AK313939 BAG36658 BC007609 AAH07609 BC053676 AAH53676 BT019523 AAV38330 L22846 AAA16890 XM_005245748 XP_005245805 XM_005245749 XP_005245806 XM_011540868 XP_011539170 XM_011540869 XP_011539171 XM_011540870 XP_011539172 XM_011540871 XP_011539173 NM_004091 NP_004082
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.
Subcellular Location Nucleus.
Tissue Specificity Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.
Top Pathways MicroRNAs in cancer, Cell cycle, HTLV-I infection, Prostate cancer, Glioma