PLA2G4A

Gene Symbol PLA2G4A
Entrez Gene 5321
Alt Symbol PLA2G4, cPLA2-alpha
Species Human
Gene Type protein-coding
Description phospholipase A2, group IVA (cytosolic, calcium-dependent)
Other Description cPLA2|calcium-dependent phospholipid-binding protein|cytosolic phospholipase A2|lysophospholipase|phosphatidylcholine 2-acylhydrolase|phospholipase A2 group IVA
Swissprots Q29R80 B1AKG4 P47712
Accessions AAS45712 AHF45879 BAA07375 EAW91217 EAW91218 P47712 AK290336 BAF83025 AK302938 BAG64096 BC114340 AAI14341 BX118890 DA451491 M68874 AAA60105 M72393 AAB00789 XM_005245267 XP_005245324 XM_011509641 XP_011507943 XM_011509642 XP_011507944 XM_011509643 XP_011507945 XR_921838 NM_024420 NP_077734
Function Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Subcellular Location Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.
Tissue Specificity Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
Top Pathways Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, VEGF signaling pathway, Inflammatory mediator regulation of TRP channels