NNT

Gene Symbol NNT
Entrez Gene 23530
Alt Symbol GCCD4
Species Human
Gene Type protein-coding
Description nicotinamide nucleotide transhydrogenase
Other Description NAD(P) transhydrogenase, mitochondrial|pyridine nucleotide transhydrogenase
Swissprots Q2TB60 Q13423 Q16796 Q8N3V4
Accessions EAW56073 EAW56074 Q13423 AK297558 BAG59951 AK299622 BAG61550 AL831822 CAD38536 AM392664 CAL37542 AM393615 CAL38491 AW771969 BC032370 AAH32370 BC064402 BC110543 AAI10544 BC110544 AAI10545 BU429380 DA521839 U40490 AAC51914 Z50101 CAA90428 XM_005248274 XP_005248331 XM_005248275 XP_005248332 XM_006714461 XP_006714524 XM_011514001 XP_011512303 XM_011514002 XP_011512304 NM_012343 NP_036475 NM_182977 NP_892022
Function The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. {ECO:0000269|PubMed:22634753}.
Subcellular Location Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Tissue Specificity Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. {ECO:0000269|PubMed:22634753}.
Top Pathways Nicotinate and nicotinamide metabolism