| Gene Symbol | ITGA1 |
|---|---|
| Entrez Gene | 3672 |
| Alt Symbol | CD49a, VLA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | integrin, alpha 1 |
| Other Description | CD49 antigen-like family member A|VLA-1|integrin alpha-1|laminin and collagen receptor|very late activation protein 1 |
| Swissprots | B2RNU0 P56199 |
| Accessions | CCF77001 P56199 AK300423 BAG62150 BC050277 BC137121 AAI37122 BC137122 AAI37123 BX640981 BX648284 X68742 NM_181501 NP_852478 |
| Function | Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. {ECO:0000269|PubMed:15592458}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Top Pathways | Focal adhesion, ECM-receptor interaction, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC) |