| Gene Symbol | ATP5B |
|---|---|
| Entrez Gene | 506 |
| Alt Symbol | ATPMB, ATPSB, HEL-S-271 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide |
| Other Description | ATP synthase subunit beta, mitochondrial|epididymis secretory protein Li 271|mitochondrial ATP synthase beta subunit|mitochondrial ATP synthetase, beta subunit |
| Swissprots | A8K4X0 P06576 Q14283 |
| Accessions | AAA51808 AAA51809 CBI68016 EAW96952 P06576 AK291085 BAF83774 BC016512 AAH16512 BI561028 DQ403107 ABD77240 DQ891585 ABM82511 DQ894779 ABM85705 FJ224288 ACI45980 X05606 CAA29095 NM_001686 NP_001677 |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. |
| Subcellular Location | Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |