| Gene Symbol | MAPK11 |
|---|---|
| Entrez Gene | 5600 |
| Alt Symbol | P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase 11 |
| Other Description | MAP kinase 11|MAP kinase p38 beta|mitogen-activated protein kinase p38 beta|mitogen-activated protein kinase p38-2|stress-activated protein kinase-2|stress-activated protein kinase-2b |
| Swissprots | O15472 B0LPG1 O00284 Q15759 L7RT27 A8K730 Q2XNF2 E7ETQ1 B7Z630 |
| Accessions | ABB72677 ABY87540 AGC09598 EAW73524 EAW73525 EAW73526 Q15759 AF001008 AAC51250 AF001174 AAC51373 AF031135 AAC12714 AK291845 BAF84534 AK299745 BAH13116 AK308969 AK309046 BC027933 AAH27933 BM857051 BX361670 BX444192 CR456514 CAG30400 CU013114 CAK54545 CU013402 CAK54844 DQ891728 ABM82654 DQ894905 ABM85831 U53442 AAB05036 U92268 AAB66313 Y14440 CAA74792 XM_011530706 XP_011529008 NM_002751 NP_002742 NR_110887 |
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid indu |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Tissue Specificity | Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Top Pathways | VEGF signaling pathway, Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Retrograde endocannabinoid signaling, Proteoglycans in cancer |