| Gene Symbol | AOC2 |
|---|---|
| Entrez Gene | 314 |
| Alt Symbol | DAO2, RAO |
| Species | Human |
| Gene Type | protein-coding |
| Description | amine oxidase, copper containing 2 (retina-specific) |
| Other Description | SSAO|retina-specific copper amine oxidase|semicarbazide-sensitive amine oxidase |
| Swissprots | O75105 O75106 Q9UNY0 Q4TTW5 O00120 A5PKW2 |
| Accessions | AAY43129 BAA32589 BAA32590 EAW60895 EAW60896 O75106 AF081363 AAD39345 BC142641 AAI42642 CA425343 CN355968 D88213 BAA19001 DQ426861 ABD90530 NM_001158 NP_001149 NM_009590 NP_033720 |
| Function | Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076}. |
| Subcellular Location | Isoform 1: Cell membrane; Peripheral membrane protein. Note=Present on the surface of the cells. |
| Tissue Specificity | Expressed in many tissues with much higher expression in retina. Isoform 1 and isoform 2 are expressed in adipose tissue, whereas isoform 1 only seems to be present in thymus, and isoform 2 only in testis. {ECO:0000269|PubMed:12755418, ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076}. |
| Top Pathways | Glycine, serine and threonine metabolism, Phenylalanine metabolism, Tyrosine metabolism, beta-Alanine metabolism |