| Gene Symbol | MAGOH |
|---|---|
| Entrez Gene | 4116 |
| Alt Symbol | MAGOH1, MAGOHA |
| Species | Human |
| Gene Type | protein-coding |
| Description | mago-nashi homolog, proliferation-associated (Drosophila) |
| Other Description | protein mago nashi homolog |
| Swissprots | O35169 Q5SW69 B2R5A2 B1ARP8 P50606 P61326 |
| Accessions | EAX06747 EAX06748 P61326 AF035940 AAC39606 AF067173 AAD32457 AF086246 AK297895 BAG60216 AK312113 BAG35049 BC018211 AAH18211 BX283982 DQ891289 ABM82215 DQ894473 ABM85399 NM_002370 NP_002361 |
| Function | Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and transla |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:19324961}. Nucleus speckle {ECO:0000269|PubMed:19324961}. Cytoplasm {ECO:0000269|PubMed:19324961}. Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | Spliceosome, RNA transport, mRNA surveillance pathway |