| Gene Symbol | Papss1 |
|---|---|
| Entrez Gene | 23971 |
| Alt Symbol | AI325286, Asapk, SK1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
| Other Description | PAPS synthase 1|PAPSS 1|SK 1|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1|sulfurylase kinase 1 |
| Swissprots | Q60967 |
| Accessions | EDL12197 EDL12198 Q60967 AK146507 BAE27221 AK153296 BAE31878 AK160875 BAE36063 AK168982 BAE40782 AK169117 BAE40897 AK169124 BAE40904 AK169204 BAE40977 AK209379 AK210041 AK211888 BC066055 AAH66055 CO043332 U34883 AAC52328 NM_001289477 NP_001276406 NM_001289478 NP_001276407 NM_001289479 NP_001276408 NM_011863 NP_035993 |
| Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells. |
| Tissue Specificity | Expressed in the neonatal brain and in cartilage. |
| Top Pathways | Sulfur metabolism, Purine metabolism, Selenocompound metabolism |