| Gene Symbol | ILK |
|---|---|
| Entrez Gene | 3611 |
| Alt Symbol | HEL-S-28, ILK-1, ILK-2, P59, p59ILK |
| Species | Human |
| Gene Type | protein-coding |
| Description | integrin-linked kinase |
| Other Description | 59 kDa serine/threonine-protein kinase|epididymis secretory protein Li 28|integrin-linked kinase-2|integrin-linked protein kinase |
| Swissprots | Q68DZ3 D3DQU0 B7Z418 B7Z1I0 Q13418 P57043 |
| Accessions | AAF74449 CAB99253 EAW68688 EAW68689 EAW68690 Q13418 AB209416 BAD92653 AK293474 BAH11516 AK296628 BAH12404 AK314843 BC001554 AAH01554 CB113885 CR407673 CAG28601 CR749220 CAH18077 DC379936 DC380243 DQ891172 ABM82098 DQ894355 ABM85281 EU794625 ACJ13679 HY257434 U40282 AAC16892 XM_005252904 XP_005252961 XM_005252905 XP_005252962 XM_011520065 XP_011518367 NM_001014794 NP_001014794 NM_001014795 NP_001014795 NM_001278441 NP_001265370 NM_001278442 NP_001265371 NM_004517 NP_004508 |
| Function | Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. |
| Subcellular Location | Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, myofibril, sarcomere. |
| Tissue Specificity | Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver. |
| Top Pathways | Focal adhesion, Endometrial cancer, PPAR signaling pathway, Bacterial invasion of epithelial cells |