Ppp1r12a

Gene Symbol Ppp1r12a
Entrez Gene 17931
Alt Symbol 1200015F06Rik, 5730577I22Rik, AA792106, AV099298, D10Ertd625e, Mypt1
Species Mouse
Gene Type protein-coding
Description protein phosphatase 1, regulatory (inhibitor) subunit 12A
Other Description myosin phosphatase target subunit 1|myosin phosphatase, target subunit 1|myosin phosphatase-targeting subunit 1|protein phosphatase 1 regulatory subunit 12A
Swissprots Q99NB6 Q8CBV2 Q05A74 Q9DBR7
Accessions BAB39108 EDL21699 EDL21700 EDL21702 EDL21703 Q9DBR7 AK004785 BAB23563 AK030460 AK035230 BAC28990 AK077739 AK139570 AK162199 BAE36787 AK182043 BC054076 BC125381 AAI25382 BC137630 AAI37631 XM_006513326 XP_006513389 XM_006513327 XP_006513390 XM_006513328 XP_006513391 XM_006513329 XP_006513392 NM_027892 NP_082168
Function Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Note=Along actomyosin filaments and stress fibers. {ECO:0000250}.
Tissue Specificity Expressed in striated and vascular smooth muscle, specificcally in type 2a fibers (at protein level). Expression levels are 20-30% higher in developed males than females (at protein level). {ECO:0000269|PubMed:20634291}.
Top Pathways Focal adhesion, Vascular smooth muscle contraction, Oxytocin signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway