| Gene Symbol | CDKN2A |
|---|---|
| Entrez Gene | 1029 |
| Alt Symbol | ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase inhibitor 2A |
| Other Description | CDK4 inhibitor p16-INK4|cell cycle negative regulator beta|cyclin-dependent kinase 4 inhibitor A|cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)|multiple tumor suppressor 1 |
| Swissprots | Q13399 A5X2G7 Q9NP05 Q5VVJ5 O95440 Q8N726 D3DRK2 P42771 D3DRK1 Q7KZR9 Q16360 Q13195 Q96B52 Q15191 |
| Accessions | AAB60645 AAD02319 AAD14048 AAM77919 AAR05391 ABC50001 ABD72255 ABS32187 BAB91133 CAA63870 CBX54364 CCQ43815 EAW58598 EAW58599 EAW58600 EAW58601 EAW58602 EAW58603 P42771 Q8N726 AF115544 AAD11437 AI859822 AJ844636 CAH59950 AL582909 BC015960 AAH15960 BC021998 AAH21998 BI258230 BQ012762 BT007020 AAP35666 BX099567 DQ318021 ABC47036 JQ694043 AFN61598 JQ694044 AFN61599 JQ694045 AFN61600 KF311101 L27211 AAA92554 S78535 AAC60649 U26727 AAA82236 U38945 AAB01737 XM_005251343 XP_005251400 XM_011517675 XP_011515977 XM_011517676 XP_011515978 XM_011517677 XP_011515979 XM_011517678 XP_011515980 XM_011517679 XP_011515981 XR_929159 XR_929161 XR_929162 XR_929163 XR_929164 XR_929165 XR_929166 NM_000077 NP_000068 NM_001195132 NP_001182061 NM_058195 NP_478102 NM_058197 NP_478104 NM_058196 |
| Function | Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts wi |
| Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:18305112, ECO:0000269|PubMed:22094112}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18305112}. |
| Tissue Specificity | Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific. {ECO:0000269|PubMed:10445844}. |
| Top Pathways | Cell cycle, Glioma, Pancreatic cancer, Non-small cell lung cancer, Bladder cancer |