| Gene Symbol | Dhfr |
|---|---|
| Entrez Gene | 24312 |
| Alt Symbol | Dhfr1 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | dihydrofolate reductase |
| Other Description | Dihydrofolate reductase 1 (active) |
| Swissprots | Q920D2 |
| Accessions | EDM10015 Q920D2 AF318150 AAL11500 BC158583 AAI58584 NM_130400 NP_569084 |
| Function | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 (By similarity). {ECO:0000250}. |
| Top Pathways | Folate biosynthesis, One carbon pool by folate |