C8A

Gene Symbol C8A
Entrez Gene 731
Alt Symbol -
Species Human
Gene Type protein-coding
Description complement component 8, alpha polypeptide
Other Description complement component 8 subunit alpha|complement component C8 alpha chain
Swissprots Q13668 A2RUI4 P07357 A2RUI5 Q9H130
Accessions AAA82124 EAX06644 EAX06645 EAX06646 P07357 AK309596 BC020702 AAH20702 BC132911 AAI32912 BC132913 AAI32914 HQ258328 ADR83082 M16974 AAA52200 XM_011542079 XP_011540381 NM_000562 NP_000553
Function Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. {ECO:0000269|PubMed:17872444, ECO:0000269|PubMed:7440581}.
Subcellular Location Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells.
Top Pathways Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Amoebiasis

C8A CRISPR/Cas9 KO Plasmid (h) - sc-406590 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C8A HDR Plasmid (h) - sc-406590-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C8A Double Nickase Plasmid (h) - sc-406590-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C8A Double Nickase Plasmid (h2) - sc-406590-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C8A CRISPR Activation Plasmid (h) - sc-406590-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C8A CRISPR Activation Plasmid (h2) - sc-406590-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C8A Lentiviral Activation Particles (h) - sc-406590-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C8A Lentiviral Activation Particles (h2) - sc-406590-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C8α siRNA (h) - sc-88706 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

C8α shRNA Plasmid (h) - sc-88706-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

C8α shRNA (h) Lentiviral Particles - sc-88706-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU059301 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5123 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5123 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03963 from Sigma-Aldrich

Category miRNA

C8A siRNA (Human) - CRH0508 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

C8A - MBS8214061 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

C8A CRISPR/Cas9 KO Plasmid (h2) - sc-406590-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C8A HDR Plasmid (h2) - sc-406590-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human C8A (NM_000562.2) - SHH252581 from Creative biogene

Category siRNA
Species Reactivities Human

Human C8A siRNA - orb261010 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

C8A shRNA Plasmid (Human) - CHH0508 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

C8A miRNA 3'UTR clone - MiUTR3H-00523 from Creative biogene

Species Reactivities Human
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