| Gene Symbol | CD8B |
|---|---|
| Entrez Gene | 926 |
| Alt Symbol | CD8B1, LEU2, LY3, LYT3, P37 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD8b molecule |
| Other Description | CD8 antigen, beta polypeptide 1 (p37)|T lymphocyte surface glycoprotein beta chain|T-cell surface glycoprotein CD8 beta chain |
| Swissprots | Q9UDB4 Q9UDB8 P14861 Q9UQ55 Q9UDB9 Q496E2 Q9UDB7 P10966 Q496E1 Q9UDC0 P14860 Q9UDB6 Q496E0 Q9UDB5 Q15980 |
| Accessions | AAA52283 AAB21668 AAB21669 AAB21670 AAB21671 AAB21672 AAD13877 AAK91556 AAK91557 AAY24019 CCF76959 CCF76960 CCF76961 CCF76962 P10966 AK303360 BAG64420 AK303595 BAG64610 AW296309 AW611750 BC100911 AAI00912 BC100912 AAI00913 BC100913 AAI00914 BC100914 AAI00915 BP392114 BQ004743 DB223179 DC405359 M36712 AAA35664 X13444 CAA31795 X13445 CAA31796 X13446 CAA31797 X13452 CAA31803 Y00805 CAA68750 XM_011533164 XP_011531466 NM_001178100 NP_001171571 NM_004931 NP_004922 NM_172101 NP_742099 NM_172102 NP_742100 NM_172213 NP_757362 NM_172099 |
| Function | Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. |
| Subcellular Location | Isoform 7: Secreted {ECO:0000305}. |
| Tissue Specificity | Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells. {ECO:0000269|PubMed:8436166}. |
| Top Pathways | Hematopoietic cell lineage, T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Antigen processing and presentation |