BCL2A1

Gene Symbol BCL2A1
Entrez Gene 597
Alt Symbol ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1
Species Human
Gene Type protein-coding
Description BCL2-related protein A1
Other Description bcl-2-like protein 5|bcl-2-related protein A1|bcl2-L-5|hematopoietic BCL2-related protein A1|hemopoietic-specific early response protein|protein BFL-1
Swissprots Q86W13 Q16548 Q6FGZ4 Q99524 Q6FH19
Accessions CBX47512 EAW99129 Q16548 AL110097 AY234180 AAO89009 BC016281 AAH16281 BG198875 BG204033 BG216703 BT007103 AAP35767 CD640106 CR541937 CAG46735 CR541962 CAG46760 DQ891109 ABM82035 DQ894290 ABM85216 U27467 AAC50288 U29680 AAC50438 Y09397 CAA70566 NM_001114735 NP_001108207 NM_004049 NP_004040
Function Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm.
Tissue Specificity Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies.
Top Pathways Transcriptional misregulation in cancer