| Gene Symbol |
SFN
|
| Entrez Gene |
528453
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
stratifin
|
| Other Description |
14-3-3 protein sigma|epithelial cell marker protein 1
|
| Swissprots |
Q0VC36
|
| Accessions |
DAA32117 Q0VC36 BC120373 AAI20374 NM_001075912 NP_001069380
|
| Function |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}. Note=May be secreted by a non-classical secretory pathway. {ECO:0000250}.
|
| Top Pathways |
Cell cycle, p53 signaling pathway, Aldosterone-regulated sodium reabsorption
|
