| Gene Symbol | CYP4F3 |
|---|---|
| Entrez Gene | 4051 |
| Alt Symbol | CPF3, CYP4F, LTB4H |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 4, subfamily F, polypeptide 3 |
| Other Description | 20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVF3|cytochrome P-450|cytochrome P450 4F3|cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase)|cytochrome P450-LTB-omega|docosahexaenoic acid omega-hydroxylase CYP4F3|leukotriene B4 omega hydroxylase|leukotriene-B(4) 20-monooxygenase 2|leukotriene-B(4) omega-hydroxylase 2|leukotriene-B4 20-monooxygenase |
| Swissprots | O60634 Q5U740 B7Z8Z3 Q08477 |
| Accessions | AAV40834 BAA25991 EAW84488 EAW84489 EAW84490 EAW84491 Q08477 AB002454 BAA25990 AF054821 AAC08589 AK296761 BAH12428 AK296802 BAH12435 AK298675 BAH12844 AK303477 BAH13972 AK304200 BAH14129 AK316136 BAH14507 BC136299 AAI36300 D12620 BAA02144 D12621 BAA02145 DB184202 XM_005259911 XP_005259968 XM_011528014 XP_011526316 NM_000896 NP_000887 NM_001199208 NP_001186137 NM_001199209 NP_001186138 |
| Function | Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid. {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:8486631}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract. {ECO:0000269|PubMed:11461919}. |
| Top Pathways | Arachidonic acid metabolism |