AAK1

Gene Symbol	AAK1
Entrez Gene	22848
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	AP2 associated kinase 1
Other Description	AP2-associated protein kinase 1|adaptor-associated kinase 1
Swissprots	Q4ZFZ3 Q2M2I8 Q9UPV4 Q53RX6
Accessions	AAX88861 AAY14931 EAW99847 EAW99848 Q2M2I8 AB028971 BAA83000 AF090100 AF090101 AK055622 AK056043 AK074292 AK098797 AK124872 AK127187 BAC86877 AK310951 AW451954 AW969393 BC002695 AAH02695 BC073953 BC090950 BC104842 AAI04843 BC111965 AAI11966 BC132937 BC132939 BC143710 AAI43711 BX640963 BX641060 CA436375 DA121999 DB285703 NM_014911 NP_055726
Function	Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. {ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124}.
Subcellular Location	Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells (By similarity). {ECO:0000250}.
Tissue Specificity	Detected in brain, heart and liver. Isoform 1 is the predominant isoform in brain. {ECO:0000269|PubMed:17494869}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AAK1 full length protein - ab153192 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human AAK1 protein fragment - ab153193 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

AAK1 Antibody Blocking Peptide - LS-E3427 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AAK1 Antibody Blocking Peptide - LS-E27179 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AAK1 Antibody Blocking Peptide - LS-E9321 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AAK1 Antibody Blocking Peptide - LS-E9322 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AAK1 Antibody Blocking Peptide - LS-E30583 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

AAK1 Antibody Blocking Peptide - LS-E30588 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

AAK1 Antibody Blocking Peptide - LS-E19897 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AAK1 Antibody Blocking Peptide - LS-E19898 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human AAK1 Protein - H00022848-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human AAK1 Protein - H00022848-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

AAK1 Blocking Peptide - NBP1-77335PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

AAK1 Blocking Peptide - NBP1-76343PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

AAK1-Antibody-C-term-Blocking-Peptide - BP7861b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AAK1-Antibody-N-term-Blocking-Peptide - BP7861a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AAK1 blocking peptide - GTX88323-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

AAK1 Blocking Peptide - 33R-10925 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

AAK1 Blocking Peptide - 33R-8453 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Aak1 Blocking Peptide - 33R-1440 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AAK1 Peptide - AC21-1999-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

AAK1 - H00022848-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

AAK1 - H00022848-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

AAK1 - H00022848-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AAK1 - H00022848-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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