Gene Symbol | UBE2S |
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Entrez Gene | 27338 |
Alt Symbol | E2-EPF, E2EPF, EPF5 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin-conjugating enzyme E2S |
Other Description | E2-EPF5|ubiquitin carrier protein S|ubiquitin-conjugating enzyme E2 S|ubiquitin-conjugating enzyme E2-24 kD|ubiquitin-conjugating enzyme E2-24 kDa|ubiquitin-conjugating enzyme E2-EPF5|ubiquitin-protein ligase S |
Swissprots | Q16763 Q9BTC1 |
Accessions | ABC40675 EAW72377 Q16763 AB062397 BAB93484 BC004236 AAH04236 BC007554 AAH07554 BC065364 AAH65364 BC066948 AAH66948 CA421746 CN305224 HQ448521 ADQ33000 M91670 AAA58446 XM_011526752 XP_011525054 XM_011526753 XP_011525055 NM_014501 NP_055316 |
Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000 |
Top Pathways | Ubiquitin mediated proteolysis |
UBE2S (D5H9H) Rabbit mAb - 11878 from Cell Signaling Technology
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UBE2S Antibody - 9630 from Cell Signaling Technology
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UBE2S (C-1) - sc-390917 from Santa Cruz Biotechnology
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UBE2S (F-10) - sc-398339 from Santa Cruz Biotechnology
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UBE2S (N-14) - sc-131354 from Santa Cruz Biotechnology
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UBE2S (H-87) - sc-367058 from Santa Cruz Biotechnology
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UBE2S (P-14) - sc-131355 from Santa Cruz Biotechnology
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Anti-UBE2S antibody - ab197945 from Abcam
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Anti-UBE2S antibody [1B5] - ab131608 from Abcam
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Anti-UBE2S antibody [AT2C12] - ab93904 from Abcam
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Anti-UBE2S antibody - C-terminal - ab156204 from Abcam
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Anti-UBE2S / E2 EPF Antibody - LS-C113040 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (aa1-222) - LS-C132795 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (aa2-14) - LS-C54752 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (aa183-210, APC) - LS-C272921 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (aa183-210, AP) - LS-C272922 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (aa183-210, Biotin) - LS-C272923 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (aa183-210, FITC) - LS-C272924 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (clone 2G7) - LS-C139228 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (aa183-210, Azide-free, HRP) - LS-C272925 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (aa183-210, PE) - LS-C272927 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (N-Terminus) - LS-C102005 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (N-Terminus, AP) - LS-C284001 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (N-Terminus, Biotin) - LS-C284003 from LifeSpan Bioscience
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Anti-UBE2S / E2 EPF Antibody (N-Terminus, APC) - LS-C284004 from LifeSpan Bioscience
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