| Gene Symbol | ITPA |
|---|---|
| Entrez Gene | 3704 |
| Alt Symbol | C20orf37, HLC14-06-P, My049, dJ794I6.3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) |
| Other Description | ITPase|NTPase|inosine triphosphatase-A|inosine triphosphate pyrophosphatase|inosine triphosphate pyrophosphohydrolase|non-canonical purine NTP pyrophosphatase|non-standard purine NTP pyrophosphatase|nucleoside-triphosphate diphosphatase|putative oncogene protein HLC14-06-P |
| Swissprots | A2A2N2 A4UIM5 O14878 B2BCH7 Q9BYN1 Q9BY32 Q9BYX0 Q5JWH4 Q9H3H8 |
| Accessions | BAD81025 EAX10540 EAX10541 EAX10542 Q9BY32 AB062127 BAB93459 AF026816 AAB82608 AF063607 AAG43165 AF219116 AAK21848 AF334680 AAL57168 AK309165 AV694278 BC010138 AAH10138 BF969192 BI115811 BM560812 BQ049090 CA425905 DQ896125 ABM87124 EF199841 ABP01354 EF213026 ABO70316 EU176384 ABW03835 XM_006723564 XP_006723627 XM_006723565 XP_006723628 XM_011529234 XP_011527536 XM_011529235 XP_011527537 NM_001267623 NP_001254552 NM_033453 NP_258412 NM_181493 NP_852470 NR_052000 NR_052001 NR_052002 |
| Function | Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528}. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832}. |
| Tissue Specificity | Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland. |
| Top Pathways | Purine metabolism, Drug metabolism - other enzymes, Pyrimidine metabolism |