| Gene Symbol | CTSC |
|---|---|
| Entrez Gene | 1075 |
| Alt Symbol | CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS |
| Species | Human |
| Gene Type | protein-coding |
| Description | cathepsin C |
| Other Description | cathepsin J|dipeptidyl peptidase 1|dipeptidyl peptidase I|dipeptidyl transferase|dipeptidyl-peptidase I |
| Swissprots | P53634 Q71E76 Q8WYA7 Q2HIY8 Q7Z3G7 Q8WY99 Q8WYA8 A8K7V2 Q7M4N9 Q53G93 Q7Z5U7 Q71E75 B5MDD5 |
| Accessions | AAC51341 AFK75976 AFK75977 AFK75978 AFK75979 AFK75980 AFK75981 AFK75982 AFK75983 AFK75984 AFK75985 AFK75986 AFK75987 AFK75988 AFK75989 AFK75990 AFK75991 AFK75992 AFK75993 AFK75994 AFK75995 AFK75996 AFK75997 AFK75998 AFK75999 AFK76000 AFK76001 AFK76002 AFK76003 AFK76004 AFK76005 AFK76006 AFK76007 AFK76008 AFK76009 AFK76010 AFK76011 AFK76012 AFK76013 AFK76014 AFK76015 AFK76016 AFK76017 AFK76018 AFK76019 AFK76020 AFK76021 AFK76022 AFK76023 AFK76024 AFK76025 AFK76026 AFK76027 AFK76028 AFK76029 EAW59363 EAW59364 P53634 AA011305 AF234263 AAL48191 AF234264 AAL48192 AF254757 AAL48195 AF525032 AAQ08887 AF525033 AAQ08888 AI821972 AK223038 BAD96758 AK292117 BAF84806 AK296190 BAG58920 AK311923 BAG34864 AM393622 CAL38498 AU076460 BC023559 BC054028 AAH54028 BC100891 AAI00892 BC100892 AAI00893 BC100893 AAI00894 BC100894 AAI00895 BC107770 BC109386 AAI09387 BC110071 AAI10072 BC113850 AAI13851 BC113897 AAI13898 BC146692 AAI46693 BM997817 BX459226 BX537913 CAD97897 CB114425 CN368896 X87212 CAA60671 NM_001114173 NP_001107645 NM_001814 NP_001805 NM_148170 NP_680475 |
| Function | Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. {ECO:0000269|PubMed:1586157}. |
| Subcellular Location | Lysosome. |
| Tissue Specificity | Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas. {ECO:0000269|PubMed:9092576}. |
| Top Pathways | Lysosome |