| Gene Symbol | HHEX |
|---|---|
| Entrez Gene | 3087 |
| Alt Symbol | HEX, HMPH, HOX11L-PEN, PRH, PRHX |
| Species | Human |
| Gene Type | protein-coding |
| Description | hematopoietically expressed homeobox |
| Other Description | hematopoietically-expressed homeobox protein HHEX|homeobox protein HEX|homeobox protein PRH|homeobox, hematopoietically expressed|proline-rich homeodomain-containing transcription factor |
| Swissprots | B1AQ17 Q03014 Q96CE9 |
| Accessions | AAK12833 EAW50087 EAW50088 Q03014 AA810064 AK309463 AK314891 BAG37405 BC014336 AAH14336 BC015110 AAH15110 BC050638 AAH50638 BI823658 BM543214 DB504532 EU446478 ABZ92007 L16499 AAA02988 X67235 CAA47661 Z21533 CAA79730 NM_002729 NP_002720 |
| Function | Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Liver and promyelocytic leukemia cell line HL- 60. {ECO:0000269|PubMed:1360645, ECO:0000269|PubMed:8096636, ECO:0000269|PubMed:8103988}. |
| Top Pathways | Maturity onset diabetes of the young, Transcriptional misregulation in cancer |