| Gene Symbol | GYPC |
|---|---|
| Entrez Gene | 2995 |
| Alt Symbol | CD236, CD236R, GE, GPC, GPD, GYPD, PAS-2, PAS-2' |
| Species | Human |
| Gene Type | protein-coding |
| Description | glycophorin C (Gerbich blood group) |
| Other Description | glycoconnectin|glycophorin-C|glycophorin-D|glycoprotein beta|sialoglycoprotein D |
| Swissprots | P04921 B2R522 Q92642 Q53SV9 |
| Accessions | AAA52626 AAK01459 AAV80423 AAY14660 ABV55110 ABV55111 ABV55112 ABV69701 ABV69702 ABW82797 ABW82798 ABW82799 CAA32093 CAA32458 EAW95275 EAW95276 P04921 AA913940 AK312032 BAG34969 BC016653 BC104246 AAI04247 BC104247 AAI04248 BC106051 AAI06052 CB992018 M11802 AAA60023 M28335 AAA52574 M36284 AAA52625 X12496 CAA31016 X51973 CAA36235 XM_006712460 XP_006712523 NM_001256584 NP_001243513 NM_002101 NP_002092 NM_016815 NP_058131 |
| Function | This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. |
| Subcellular Location | Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1. |
| Tissue Specificity | Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed. {ECO:0000269|PubMed:2349119}. |
| Top Pathways | Malaria |