CISH

Gene Symbol CISH
Entrez Gene 1154
Alt Symbol BACTS2, CIS, CIS-1, G18, SOCS
Species Human
Gene Type protein-coding
Description cytokine inducible SH2-containing protein
Other Description cytokine-inducible SH2-containing protein|cytokine-inducible inhibitor of signaling type 1B|suppressor of cytokine signaling
Swissprots Q9NS38 Q9Y5R1 G5E9R1 B2R9N1 Q9NSE2
Accessions AAQ13420 EAW65127 EAW65128 EAW65129 EAW65130 Q9NSE2 AF035947 AAF97410 AF132297 AAD28471 AK313850 BAG36578 BC031590 AAH31590 BC064354 AAH64354 BF511692 CA435538 D83532 BAA92328 DA957793 XM_011533329 XP_011531631 NM_013324 NP_037456 NM_145071 NP_659508
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. {ECO:0000269|PubMed:11032736}.
Top Pathways Jak-STAT signaling pathway, Prolactin signaling pathway