| Gene Symbol | Hmgcs2 |
|---|---|
| Entrez Gene | 24450 |
| Alt Symbol | Hmgcs1, Mt3h3mg |
| Species | Rat |
| Gene Type | protein-coding |
| Description | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) |
| Other Description | 3-hydroxy-3-methylglutary-Coenzyme A synthase 2|3-hydroxy-3-methylglutaryl coenzyme A synthase|3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)|HMG-CoA synthase|hydroxymethylglutaryl-CoA synthase 2|hydroxymethylglutaryl-CoA synthase, mitochondrial |
| Swissprots | P22791 |
| Accessions | EDL85567 EDL85568 P22791 BC078695 AAH78695 BC083543 AAH83543 M33648 AAA41336 XM_006233002 XP_006233064 NM_173094 NP_775117 |
| Function | This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. |
| Subcellular Location | Mitochondrion. |
| Tissue Specificity | Liver and kidney. |
| Top Pathways | Terpenoid backbone biosynthesis, PPAR signaling pathway, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism |