C3

Gene Symbol C3
Entrez Gene 718
Alt Symbol AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
Species Human
Gene Type protein-coding
Description complement component 3
Other Description C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1|C3a anaphylatoxin|acylation-stimulating protein cleavage product|complement C3|complement component C3|complement component C3a|complement component C3b|epididymis secretory sperm binding protein Li 62p|prepro-C3
Swissprots A7E236 P01024
Accessions AAA35722 AAR89906 CAI46844 EAW69070 EAW69071 P01024 AA025232 AI758500 AK094728 AK304071 BAG64978 BC022897 BC063852 BC150179 AAI50180 BC150200 AAI50201 BC150299 BP201387 BP349355 EU794602 ACJ13656 K02765 AAA85332 KC493376 KC493377 M55658 NM_000064 NP_000055
Function C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. {ECO:0000250}.
Subcellular Location Secreted.
Tissue Specificity Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods. {ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:9555951}.
Top Pathways Phagosome, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection, Complement and coagulation cascades, Pertussis