Gls2

Gene Symbol Gls2
Entrez Gene 192268
Alt Symbol Ga
Species Rat
Gene Type protein-coding
Description glutaminase 2 (liver, mitochondrial)
Other Description GLS|L-glutaminase|L-glutamine amidohydrolase|glutaminase liver isoform, mitochondrial|liver mitochondrial glutaminase
Swissprots Q64606 Q5FVU0 P28492 Q3MHS6
Accessions EDL84884 EDL84885 P28492 BC089776 AAH89776 BC104712 AAI04713 FQ211735 J05499 AAC37707 XM_006240728 XP_006240790 XM_006240730 XP_006240792 NM_001270786 NP_001257715 NM_001270787 NP_001257716 NM_138904 NP_620259
Function Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production (By similarity). {ECO:0000250}.
Subcellular Location Mitochondrion.
Tissue Specificity Liver specific.
Top Pathways Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation