| Gene Symbol | Aox4 |
|---|---|
| Entrez Gene | 71872 |
| Alt Symbol | 2310003G12Rik, Aoh2 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | aldehyde oxidase 4 |
| Other Description | aldehyde oxidase homolog 2|aldehyde oxidase structural homolog 2|azaheterocycle hydroxylase 4|retinal oxidase |
| Swissprots | Q8VI17 Q3TYQ9 |
| Accessions | AAL38126 EDL00070 Q3TYQ9 AF233581 AAF98385 AI414378 AK009112 AK081746 AK081936 AK158427 BAE34503 AK160953 BC117975 AAI17976 BC117976 AAI17977 XM_006496286 XP_006496349 XM_006496287 XP_006496350 XM_006496288 XP_006496351 NM_023631 NP_076120 |
| Function | Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Is responsible for the major all- trans-retinaldehyde-metabolizing activity in the Harderian gland, and contributes a significant amount of the same activity in the skin. Is devoid of pyridoxal-oxidizing activity, in contrast to the other aldehyde oxidases. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles. {ECO:0000269|PubMed:18981221}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18981221}. |
| Tissue Specificity | Highly expressed in Harderian glands and sebaceous glands with detectable levels in the epidermis and other keratinized epithelia (at protein level). Detected in testis. The expression is 3 times greater in females than in males. {ECO:0000269|PubMed:18981221, ECO:0000269|PubMed:23263164}. |
| Top Pathways | Tyrosine metabolism, Vitamin B6 metabolism, Nicotinate and nicotinamide metabolism, Retinol metabolism, Tryptophan metabolism |