| Gene Symbol | NT5C |
|---|---|
| Entrez Gene | 30833 |
| Alt Symbol | DNT, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2, cdN, dNT-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | 5', 3'-nucleotidase, cytosolic |
| Other Description | 5' nucleotidase, deoxy (pyrimidine), cytosolic type C|5'(3')-deoxyribonucleotidase, cytosolic type|cytosolic 5',3'-pyrimidine nucleotidase|deoxy-5'-nucleotidase 1|epididymis luminal protein 74|uridine 5'-monophosphate phosphohydrolase 2|uridine 5-prime monophosphate hydrolase 2 |
| Swissprots | Q96HS6 Q8TCD5 Q9NP82 |
| Accessions | DAA00070 EAW89241 EAW89242 EAW89243 Q8TCD5 AF154829 AAF36534 AK000419 BAA91151 BC002516 BC008183 AAH08183 BC017454 AAH17454 BC022334 AAH22334 BC047763 BG034032 BQ431723 BU627693 EU794640 ACJ13694 HQ448006 ADQ32487 XM_006721850 XP_006721913 XM_011524700 XP_011523002 XR_429885 NM_001252377 NP_001239306 NM_014595 NP_055410 NR_045513 |
| Function | Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Detected in skeletal muscle, heart and pancreas. {ECO:0000269|PubMed:10681516}. |
| Top Pathways | Purine metabolism, Nicotinate and nicotinamide metabolism, Pyrimidine metabolism |