| Gene Symbol | CEBPB |
|---|---|
| Entrez Gene | 1051 |
| Alt Symbol | C/EBP-beta, IL6DBP, NF-IL6, TCF5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CCAAT/enhancer binding protein (C/EBP), beta |
| Other Description | CCAAT/enhancer-binding protein beta|interleukin 6-dependent DNA-binding protein|nuclear factor NF-IL6|nuclear factor of interleukin 6|transcription factor 5 |
| Swissprots | P17676 Q9H4Z5 A8K671 Q96IH2 |
| Accessions | AAN86350 CAA36794 EAW75629 P17676 AF289608 AAL55792 AK291536 BAF84225 AW025406 BC005132 AAH05132 BC007538 AAH07538 BC021931 AAH21931 BU753628 D63161 BAA09637 DB457615 EU832661 ACE87752 EU832739 ACE87071 KJ161450 AHM26727 KJ161451 AHM26728 KJ161452 AHM26729 KJ161453 AHM26730 KJ161454 AHM26731 KJ161455 AHM26732 KJ161456 AHM26733 KJ161457 AHM26734 KJ161458 AHM26735 KJ161459 AHM26736 KJ161460 AHM26737 KJ161461 AHM26738 KJ161462 AHM26739 KJ161463 AHM26740 KJ161464 AHM26741 KJ161465 AHM26742 KJ161466 AHM26743 KJ161467 AHM26744 KJ161468 AHM26745 KJ161469 AHM26746 KJ161470 AHM26747 KJ161471 AHM26748 KJ161472 AHM26749 KJ161473 AHM26750 KJ161474 AHM26751 KJ161475 AHM26752 KJ161476 AHM26753 KJ161477 AHM26754 KJ161478 AHM26755 KJ161479 AHM26756 KJ161480 AHM26757 KJ161481 AHM26758 M98056 NM_001285878 NP_001272807 NM_001285879 NP_001272808 NM_005194 NP_005185 |
| Function | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Plays an important role in adipose tissue differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) as well as other adipogenesis key player genes. {ECO:0000269|PubMed:20829347}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:20829347}. |
| Tissue Specificity | Expressed at low levels in the lung, kidney and spleen. |
| Top Pathways | Tuberculosis, TNF signaling pathway, Transcriptional misregulation in cancer |