| Gene Symbol | Wee1 |
|---|---|
| Entrez Gene | 308937 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | WEE1 G2 checkpoint kinase |
| Other Description | wee 1 homolog|wee1 tyrosine kinase|wee1-like protein kinase|wee1A kinase |
| Swissprots | Q63802 Q5EAN3 |
| Accessions | EDM17871 Q63802 BC090346 AAH90346 D31838 BAA06624 XM_006229974 XP_006230036 NM_001012742 NP_001012760 |
| Function | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Top Pathways | Cell cycle |