| Gene Symbol | CYP2E1 |
|---|---|
| Entrez Gene | 1571 |
| Alt Symbol | CPE1, CYP2E, P450-J, P450C2E |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 2, subfamily E, polypeptide 1 |
| Other Description | 4-nitrophenol 2-hydroxylase|CYPIIE1|cytochrome P450 2E1|cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1|cytochrome P450-J|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase |
| Swissprots | Q5VZD5 Q6NWT9 P05181 Q9UK47 |
| Accessions | AAA52155 ABF47105 BAA00902 BAA08796 EAW61357 EAW61358 P05181 AF084225 AAD13753 AF182276 AAF13601 AJ853939 CAH69381 AJ853940 CAH69382 AJ877238 CAI47002 AK290822 BAF83511 BC067433 AAH67433 BC067435 AAH67435 BX951478 DQ149222 AAZ77710 J02625 AAA35743 S77873 AAD14267 NM_000773 NP_000764 |
| Function | Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. |
| Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Top Pathways | Steroid hormone biosynthesis, Chemical carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), Arachidonic acid metabolism, Linoleic acid metabolism |