| Gene Symbol | BID |
|---|---|
| Entrez Gene | 637 |
| Alt Symbol | FP497 |
| Species | Human |
| Gene Type | protein-coding |
| Description | BH3 interacting domain death agonist |
| Other Description | BH3-interacting domain death agonist|BID isoform ES(1b)|BID isoform L(2)|BID isoform Si6|Human BID coding sequence|apoptic death agonist|desmocollin type 4|p22 BID |
| Swissprots | Q7Z4M9 Q71T04 P55957 Q8IY86 Q549M7 |
| Accessions | AAP50259 CAG17894 EAW57770 EAW57771 EAW57772 EAW57773 EAW57774 P55957 AF042083 AAC34365 AF087891 AAP97190 AF250233 AAO32633 AF370380 AAQ15216 AK094795 BAG52933 AK313729 BAG36471 AY005151 AAF89091 BC005884 BC009197 AAH09197 BC022072 AAH22072 BC033634 AAH33634 BC036364 AAH36364 BM561391 BM842561 BQ068464 CN277529 CR407603 CAG28531 CR456389 CAG30275 CU012947 CAK54378 CU013235 CAK54677 D89803 BAF79673 DA007047 DA158889 DA274603 DB167767 EU446512 ABZ92041 EU447348 ACA61804 EU678292 ACD47106 EU678293 ACD47107 EU678294 ACD47108 NM_001196 NP_001187 NM_001244567 NP_001231496 NM_001244569 NP_001231498 NM_001244570 NP_001231499 NM_001244572 NP_001231501 NM_197966 NP_932070 NM_197967 NP_932071 |
| Function | The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. {ECO:0000250, ECO:0000269|PubMed:14583606}. |
| Subcellular Location | Isoform 3: Cytoplasm. |
| Tissue Specificity | Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level). {ECO:0000269|PubMed:14583606}. |
| Top Pathways | Sphingolipid signaling pathway, Apoptosis, Non-alcoholic fatty liver disease (NAFLD), Tuberculosis, Amyotrophic lateral sclerosis (ALS) |