| Gene Symbol | FYN |
|---|---|
| Entrez Gene | 2534 |
| Alt Symbol | SLK, SYN, p59-FYN |
| Species | Human |
| Gene Type | protein-coding |
| Description | FYN proto-oncogene, Src family tyrosine kinase |
| Other Description | FYN oncogene related to SRC, FGR, YES|OKT3-induced calcium influx regulator|c-syn protooncogene|proto-oncogene Syn|proto-oncogene c-Fyn|src-like kinase|src/yes-related novel|tyrosine kinase p59fyn(T)|tyrosine-protein kinase Fyn |
| Swissprots | H0UI48 E1P557 Q5R3A7 Q5R3A6 Q16248 B5BU57 P06241 Q8N5D7 |
| Accessions | AAA52491 AAA52492 EAW48278 EAW48279 EAW48280 EAW48281 EAW48282 EAW48283 EAW48284 P06241 AB451293 BAG70107 AB451426 BAG70240 AI187118 AK056699 BAG51788 AY429536 BC032496 AAH32496 BI552534 BP391373 CX781584 CX872011 DA570412 DA815564 DA922886 DA931034 JF432194 ADZ15411 M14333 AAC08285 M14676 AAA36615 S74774 AAB33113 XM_005266890 XP_005266947 XM_005266892 XP_005266949 XM_011535662 XP_011533964 XM_011535663 XP_011533965 XM_011535664 XP_011533966 XM_011535665 XP_011533967 XM_011535666 XP_011533968 XM_011535667 XP_011533969 XM_011535668 XP_011533970 NM_002037 NP_002028 NM_153047 NP_694592 NM_153048 NP_694593 NM_001242779 |
| Function | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta- catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an esse |
| Subcellular Location | Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking. |
| Tissue Specificity | Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes. {ECO:0000269|PubMed:10196263}. |
| Top Pathways | Sphingolipid signaling pathway, Measles, Adherens junction, Osteoclast differentiation, Prion diseases |