| Gene Symbol | SKP2 |
|---|---|
| Entrez Gene | 6502 |
| Alt Symbol | FBL1, FBXL1, FLB1, p45 |
| Species | Human |
| Gene Type | protein-coding |
| Description | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| Other Description | CDK2/cyclin A-associated protein p45|F-box/LRR-repeat protein 1|S-phase kinase-associated protein 2|S-phase kinase-associated protein 2 (p45)|p45skp2 |
| Swissprots | Q8TDZ1 Q13309 A8K5E0 Q8TDZ0 Q9BV69 B4DJT4 |
| Accessions | AAY87142 EAW55934 EAW55935 EAW55936 EAW55937 EAW55938 Q13309 AB050979 BAB87200 AB050980 BAB87201 AB050981 BAB87202 AK026224 AK291255 BAF83944 AK295152 BAG58168 AK296223 BAG58946 AY029177 AAK31593 BC001441 AAH01441 BC007441 AAH07441 CA415778 DA223617 U33761 AAC50242 XM_011514081 XP_011512383 XM_011514082 XP_011512384 XM_011514083 XP_011512385 NM_001243120 NP_001230049 NM_005983 NP_005974 NM_032637 NP_116026 |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. {ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|Pu |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:22770219}. Nucleus {ECO:0000269|PubMed:22770219}. |
| Top Pathways | Cell cycle, Ubiquitin mediated proteolysis, Small cell lung cancer, Herpes simplex infection, Viral carcinogenesis |