PMM1

Gene Symbol PMM1
Entrez Gene 5372
Alt Symbol Sec53
Species Human
Gene Type protein-coding
Description phosphomannomutase 1
Other Description PMM 1|PMMH-22|brain glucose-1,6-bisphosphatase
Swissprots A8K003 Q92871 Q92586
Accessions EAW60443 EAW60444 Q92871 AK094811 AK130449 AK289368 BAF82057 AK316580 BAG38168 BC010855 AAH10855 BC016818 AAH16818 CR456544 CAG30430 CU013144 CAK54575 CU013432 CAK54874 D87810 BAA13460 U62526 AAC51117 U86070 AAC00023 XM_005261638 XP_005261695 XM_005261641 XP_005261698 XM_005261642 XP_005261699 XM_011530229 XP_011528531 XM_011530230 XP_011528532 XM_011530231 XP_011528533 XM_011530232 XP_011528534 NM_002676 NP_002667
Function Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:16540464}.
Subcellular Location Cytoplasm.
Tissue Specificity Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.
Top Pathways Amino sugar and nucleotide sugar metabolism, Fructose and mannose metabolism