Neu1

Gene Symbol Neu1
Entrez Gene 24591
Alt Symbol -
Species Rat
Gene Type protein-coding
Description neuraminidase 1
Other Description N-acetyl-alpha-neuraminidase 1|lysosomal sialidase|sialidase 1 (lysosomal sialidase)|sialidase-1
Swissprots Q99PW3
Accessions CAE83976 EDL83468 EDL83469 Q99PW3 AB035722 BAB21443 BC100639 AAI00640 NM_031522 NP_113710
Function Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:11162581}.
Subcellular Location Lysosome membrane {ECO:0000269|PubMed:11162581}; Peripheral membrane protein {ECO:0000269|PubMed:11162581}; Lumenal side {ECO:0000269|PubMed:11162581}. Lysosome lumen {ECO:0000269|PubMed:11162581}. Cell membrane {ECO:0000269|PubMed:11162581}. Cytoplasmic vesicle {ECO:0000269|PubMed:11162581}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
Top Pathways Lysosome, Sphingolipid metabolism, Other glycan degradation