| Gene Symbol | HSPA1L |
|---|---|
| Entrez Gene | 3305 |
| Alt Symbol | HSP70-1L, HSP70-HOM, HSP70T, hum70t |
| Species | Human |
| Gene Type | protein-coding |
| Description | heat shock 70kDa protein 1-like |
| Other Description | heat shock 10kDa protein 1-like|heat shock 70 kDa protein 1-Hom|heat shock 70 kDa protein 1-like|heat shock 70 kDa protein 1L|heat shock 70kD protein-like 1 |
| Swissprots | B0UXW8 A6NNB0 P34931 O75634 Q9UQM1 Q96QC9 Q8NE72 Q2HXR3 |
| Accessions | AAA52696 AAA63228 AAD21817 ABC88476 BAB63301 EAX03527 P34931 AK223386 BAD97106 AK295416 BAG58366 AK302179 BAG63545 AK315227 BAG37656 AM392545 CAL37423 AM392811 CAL37689 AM393413 CAL38291 BC034483 AAH34483 BG717447 BX115051 CA443193 D85730 BAA32521 XM_005249070 XP_005249127 XM_005249071 XP_005249128 XM_005249073 XP_005249130 XM_005272816 XP_005272873 XM_005272817 XP_005272874 XM_005274859 XP_005274916 XM_005274861 XP_005274918 XM_005274862 XP_005274919 XM_005274970 XP_005275027 XM_005274973 XP_005275030 XM_005274974 XP_005275031 XM_005275401 XP_005275458 XM_005275402 XP_005275459 XM_011514566 XP_011512868 XM_011546311 XP_011544613 XM_011547246 XP_011545548 XM_011547247 XP_011545549 XM_011547652 XP_011545954 XM_011548238 XP_011546540 XM_011548239 XP_011546541 NM_005527 NP_005518 |
| Function | In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). Positive regulator of PARK2 translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}. |
| Tissue Specificity | Expressed in spermatids. {ECO:0000269|PubMed:9685725}. |
| Top Pathways | Estrogen signaling pathway, Epstein-Barr virus infection, Legionellosis, Influenza A, Measles |