CDC26

Gene Symbol CDC26
Entrez Gene 850597
Alt Symbol HIT3, SCD26
Species Yeast
Gene Type protein-coding
Description anaphase promoting complex subunit CDC26
Other Description -
Swissprots D6VTR9 P14724
Accessions DAA12479 P14724 NM_001180001 NP_116694
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
Subcellular Location Nucleus {ECO:0000269|PubMed:14562095}.
Top Pathways Cell cycle - yeast, Ubiquitin mediated proteolysis, Meiosis - yeast