ATP6V0A1

Gene Symbol ATP6V0A1
Entrez Gene 535
Alt Symbol ATP6N1, ATP6N1A, Stv1, VPP1, Vph1, a1
Species Human
Gene Type protein-coding
Description ATPase, H+ transporting, lysosomal V0 subunit a1
Other Description ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD)|ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD)|H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1|V-ATPase 116 kDa|V-type proton ATPase 116 kDa subunit a|V-type proton ATPase 116 kDa subunit a isoform 1|clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit|vacuolar adenosine triphosphatase subunit Ac116|vacuolar proton pump subunit 1|vacuolar proton pump, subunit 1|vacuolar proton translocating ATPase 116 kDa subunit A|vacuolar-type H(+)-ATPase 115 kDa subunit
Swissprots Q93050 Q8N5G7 B7Z3B7 Q9NSX0
Accessions EAW60830 EAW60831 Q93050 AK098213 AK125927 AK223554 BAD97274 AK294512 BAH11795 AK294789 BAH11885 AK295682 BAH12153 AK299784 BAH13127 AK316305 BAH14676 AL096733 AL137683 CAB70874 BC032398 AAH32398 BX648978 CAI56709 CR627443 CAH10528 L78933 AAL77442 U18920 AAA69700 Z71460 CAA96077 XM_005257459 XP_005257516 XM_005257461 XP_005257518 XM_005257463 XP_005257520 XM_011524908 XP_011523210 XR_934483 XR_934484 NM_001130020 NP_001123492 NM_001130021 NP_001123493 NM_005177 NP_005168
Function Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Coated vesicle. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways Collecting duct acid secretion, Tuberculosis, Synaptic vesicle cycle, Rheumatoid arthritis, Phagosome