| Gene Symbol |
Fzd1
|
| Entrez Gene |
14362
|
| Alt Symbol |
AW227548, FZ-1, Fz1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
frizzled homolog 1 (Drosophila)
|
| Other Description |
frizzled-1|mFz1
|
| Swissprots |
O08974 Q7TS82 O70421
|
| Accessions |
EDL14633 O70421 AF005202 AAC01952 AF054623 AAC12873 AK143101 BAE25269 BC053010 AAH53010 BE948559 NM_021457 NP_067432
|
| Function |
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in chondrocytes.
|
| Top Pathways |
Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway
|