Gene Symbol | Fzd1 |
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Entrez Gene | 14362 |
Alt Symbol | AW227548, FZ-1, Fz1 |
Species | Mouse |
Gene Type | protein-coding |
Description | frizzled homolog 1 (Drosophila) |
Other Description | frizzled-1|mFz1 |
Swissprots | O08974 Q7TS82 O70421 |
Accessions | EDL14633 O70421 AF005202 AAC01952 AF054623 AAC12873 AK143101 BAE25269 BC053010 AAH53010 BE948559 NM_021457 NP_067432 |
Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
Subcellular Location | Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in chondrocytes. |
Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
frizzled-1 CRISPR/Cas9 KO Plasmid (m) - sc-420432 from Santa Cruz Biotechnology
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frizzled-1 HDR Plasmid (m) - sc-420432-HDR from Santa Cruz Biotechnology
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frizzled-1 Double Nickase Plasmid (m) - sc-420432-NIC from Santa Cruz Biotechnology
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frizzled-1 Double Nickase Plasmid (m2) - sc-420432-NIC-2 from Santa Cruz Biotechnology
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frizzled-1 CRISPR Activation Plasmid (m) - sc-420432-ACT from Santa Cruz Biotechnology
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frizzled-1 CRISPR Activation Plasmid (m2) - sc-420432-ACT-2 from Santa Cruz Biotechnology
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frizzled-1 Lentiviral Activation Particles (m) - sc-420432-LAC from Santa Cruz Biotechnology
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frizzled-1 Lentiviral Activation Particles (m2) - sc-420432-LAC-2 from Santa Cruz Biotechnology
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frizzled-1 siRNA (m) - sc-39978 from Santa Cruz Biotechnology
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frizzled-1 shRNA Plasmid (m) - sc-39978-SH from Santa Cruz Biotechnology
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frizzled-1 shRNA (m) Lentiviral Particles - sc-39978-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN31627 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31627 from Sigma-Aldrich
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FZD1 siRNA (Mouse) - CRM1443 from Cohesion Biosciences
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FZD1 - MBS8216188 from MyBioSource
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shRNA set against Mouse FZD1 (NM_021457.3) - SHH298057 from Creative biogene
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shRNA set against Mouse Fzd1(NM_021457.3) - SHH071975 from Creative biogene
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Mouse FZD1 siRNA - orb280919 from Biorbyt
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FZD1 shRNA Plasmid (Mouse) - CHM1443 from Cohesion Biosciences
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FZD1 miRNA 3'UTR clone - MiUTR1M-04851 from Creative biogene
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