| Gene Symbol | PIK3R2 |
|---|---|
| Entrez Gene | 5296 |
| Alt Symbol | MPPH, MPPH1, P85B, p85, p85-BETA |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphoinositide-3-kinase, regulatory subunit 2 (beta) |
| Other Description | PI3-kinase subunit p85-beta|PI3K regulatory subunit beta|phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta|phosphatidylinositol 3-kinase regulatory subunit beta|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)|ptdIns-3-kinase regulatory subunit p85-beta |
| Swissprots | Q5EAT5 O00459 Q9UPH9 |
| Accessions | AAD22671 EAW84659 EAW84660 O00459 BC011917 AAH11917 BC014170 AAH14170 BC032647 AAH32647 BC070082 AAH70082 BC090249 AAH90249 HY043384 X80907 CAA56868 NM_005027 NP_005018 NR_073517 |
| Function | Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin- dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). {ECO:0000250|UniProtKB:O08908, ECO:0000269|PubMed:23604317}. |
| Top Pathways | Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway |