| Gene Symbol | phm |
|---|---|
| Entrez Gene | 32857 |
| Alt Symbol | 306a1, CG6578, CYP306A1, Cyp306a1, Cyp306a1-Dm, Dmel\CG6578, PHM, exo, ptm |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | phantom |
| Other Description | CG6578-PA|CG6578-PB|cytochrome P450|exocephalon|phm-PA|phm-PB |
| Swissprots | A5AC99 Q9VWR5 A5AC97 A5AC85 |
| Accessions | AAF48873 AHN59884 CAL69929 CAL69931 CAL69933 CAL69935 CAL69937 CAL69939 CAL69945 CAL69947 CAL69949 CAL69951 CAL69953 Q9VWR5 AF484413 AAQ05971 AY070930 AAL48552 NM_001298485 NP_001285414 NM_133091 NP_573319 |
| Function | Involved in the metabolism of insect hormones; responsible for ecdysteroid C25-hydroxylase activity. May be involved in the breakdown of synthetic insecticides. {ECO:0000269|PubMed:15350618}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15350618}; Peripheral membrane protein {ECO:0000269|PubMed:15350618}. Microsome membrane {ECO:0000269|PubMed:15350618}; Peripheral membrane protein {ECO:0000269|PubMed:15350618}. |
| Tissue Specificity | First seen at the early (syncytial) blastoderm stage 4. During cellularization of the blastoderm (stage 5), stripes of expression appear and remain through to stage 10. Expression becomes undetectable during germ band retraction (stages 11-14). By stage 15, some expression resumes in the primordium of the ring gland, so that by stage 17 strong expression is seen, but only in the ring gland. This specific localization continues throughout the larval instars (at protein level). Expressed in the prothoracic gland cells of the larval ring gland (RG). Levels decline just after the molt to the third instar then increase later during the wandering stage. Low levels of expression are seen in the larval brain and fat body. In the adult, majority of expression is restricted to the ovaries, with low levels in the head and carcass of both sexes. {ECO:0000269|PubMed:15350618}. |
| Top Pathways | Insect hormone biosynthesis |