| Gene Symbol | FPR2 |
|---|---|
| Entrez Gene | 2358 |
| Alt Symbol | ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH1, FPRH2, FPRL1, HM63, LXA4R |
| Species | Human |
| Gene Type | protein-coding |
| Description | formyl peptide receptor 2 |
| Other Description | FMLP-R-I|FMLP-related receptor I|LXA4 receptor|N-formyl peptide receptor 2|RFP|formyl peptide receptor-like 1|lipoxin A4 receptor (formyl peptide receptor related) |
| Swissprots | A8K3E2 P25090 |
| Accessions | AAB23104 AAF87844 AAO67711 EAW72043 EAW72044 P25090 AF054013 AAC13684 AK290557 BAF83246 BC029125 AAH29125 BC071722 AAH71722 BM922150 D10922 BAA01720 DQ892105 ABM83031 DQ895299 ABM86225 M76672 AAA58481 M84562 AAA52473 M88107 AAA60070 U81501 AAB51133 X63819 CAA45319 XM_006723120 XP_006723183 NM_001005738 NP_001005738 NM_001462 NP_001453 |
| Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis. {ECO:0000269|PubMed:9151906}. |
| Top Pathways | Staphylococcus aureus infection, Neuroactive ligand-receptor interaction |