| Gene Symbol | CYBA |
|---|---|
| Entrez Gene | 1535 |
| Alt Symbol | p22-PHOX |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome b-245, alpha polypeptide |
| Other Description | cytochrome b light chain|cytochrome b(558) alpha chain|cytochrome b(558) alpha-subunit|cytochrome b, alpha polypeptide|cytochrome b-245 light chain|cytochrome b558 subunit alpha|flavocytochrome b-558 alpha polypeptide|neutrophil cytochrome b 22 kDa polypeptide|p22 phagocyte B-cytochrome|p22phox|superoxide-generating NADPH oxidase light chain subunit |
| Swissprots | P13498 Q9BR72 Q14090 |
| Accessions | AAM96953 ABF20535 EAW66793 EAW66794 EAW66795 EAW66796 P13498 AK097127 AK125578 AK300049 BAG61858 AK309030 BC006465 AAH06465 BC011565 BC028224 BC033739 BT006861 AAP35507 BX109994 DQ893235 ABM84161 DQ896565 ABM87564 M21186 AAA90925 XM_011522905 XP_011521207 NM_000101 NP_000092 |
| Function | Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. {ECO:0000269|PubMed:15824103}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:15585859, ECO:0000269|PubMed:22808130}. |
| Top Pathways | Leukocyte transendothelial migration, Leishmaniasis, Phagosome, Osteoclast differentiation |