| Gene Symbol | ERCC4 |
|---|---|
| Entrez Gene | 2072 |
| Alt Symbol | ERCC11, FANCQ, RAD1, XPF |
| Species | Human |
| Gene Type | protein-coding |
| Description | excision repair cross-complementation group 4 |
| Other Description | DNA excision repair protein ERCC-4|DNA repair endonuclease XPF|DNA repair protein complementing XP-F cells|excision repair cross-complementing rodent repair deficiency, complementation group 4|excision-repair, complementing defective, in Chinese hamster|xeroderma pigmentosum group F-complementing protein|xeroderma pigmentosum, complementation group F |
| Swissprots | Q8TD83 A5PKV6 Q92889 O00140 A8K111 |
| Accessions | AAB50174 AAL91593 EAW85117 EAW85118 Q92889 AI470593 AK289726 BAF82415 AK301930 BAG63350 AK308341 BC020741 AAH20741 BC142631 AAI42632 BC160102 AAI60102 U64315 AAB07689 XM_011522424 XP_011520726 XM_011522425 XP_011520727 XM_011522426 XP_011520728 XM_011522427 XP_011520729 XR_932805 NM_005236 NP_005227 |
| Function | Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. {ECO:0000269|PubMed:19596235}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Top Pathways | Nucleotide excision repair, Fanconi anemia pathway |